Metabolic adaptations during lactogenesis. Fatty acid and lactose synthesis in cow mammary tissue
نویسندگان
چکیده
منابع مشابه
Progesterone and the metabolic control of the lactose biosynthetic pathway during lactogenesis in the rat.
1. Lactogenesis was initiated in pregnant rats by ovariectomy, thereby causing progesterone withdrawal, after which the mammary tissue was analysed for contents of enzymes and metabolites concerned with the biosynthesis of lactose. 2. Lactose synthesis increased about 126-fold with little or no accompanying change in the contents of most metabolic intermediates or in the adenine nucleotide ener...
متن کاملEffects of glucose on lactose synthesis in mammary epithelial cells from dairy cow.
BACKGROUND Lactose, as the primary osmotic component in milk, is the major determinant of milk volume. Glucose is the primary precursor of lactose. However, the effect of glucose on lactose synthesis in dairy cow mammary glands and the mechanism governing this process are poorly understood. RESULTS Here we showed that glucose has the ability to induce lactose synthesis in dairy cow mammary ep...
متن کاملChain-Termination Mechanism in Fatty Acid Synthesis by Mammalian Fatty Acid Synthetase SYNTHESIS OF BUTYRATE AND HEXANOATE BY LACTATING COW MAMMARY GLAND
1. Purified cow mammary gland fatty acid synthetase synthesized long-chain unesterifled and short-chain esterified fatty acids. 2. A direct relationship was observed between the amount of short-chain products synthesized and the concentration of acetyl-CoA in the incubation medium. 3. The short-chain products were identified as butyryl-CoA and hexanoyl-CoA. 4. Inhibition of the terminating thio...
متن کاملFatty Acid Synthesis in Human Adipose Tissue*
The concentration of enzymes required for fatty acid synthesis was considerably less in extracts prepared from human omental adipose tissue than from rat epididymal fat. Overall rates of synthesis as measured by the incorporation of radioactive precursors into fatty acids were also much lower in human adipose tissue. The most striking difference was found with citrate-1,5-W, human adipose tissu...
متن کاملFatty acid synthesis by human adipose tissue.
The effect of age and nutritional status on the synthesis of fatty acids from a variety of labeled substrates by human adipose tissue in vitro was investigated. The results of this study clearly demonstrate that, although human adipose tissue is able to oxidize glucose to CO2, its ability to incorporate glucose-carbon into long chain fatty acids is negligible. Although the utilization of acetat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1973
ISSN: 0306-3283
DOI: 10.1042/bj1360741